Key result
Nonsecretors were as likely to develop symptomatic norovirus gastroenteritis as secretors (OR 1.41), demonstrating a secretor-independent susceptibility pattern in this GI.3 outbreak.
Population
83 healthcare workers attending a seminar in Jönköping, Sweden, exposed to a foodborne Norovirus GI.3…
Design
Case-control
Follow-up
up to 60 hours after exposure
Authors
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May affect nonsecretors equally in GI.3 outbreaks; leaves open generalizability of secretor-independent susceptibility.
Case-Control (n=83)
No
Odds Ratio: 1.41 (95% CI 0.46–4.36)
Absolute Event Rate: 47% vs 38%
p-value: p=0.57
This study demonstrates that a Norovirus GI.3 outbreak infected individuals regardless of their secretor status or Lewis/ABO phenotypes, challenging the previous understanding that nonsecretors are almost completely resistant to the disease.
Nordgren et al. (2009) conducted a case-control in Norovirus gastroenteritis (n=83). Nonsecretor status vs. Secretor status was evaluated on Symptomatic norovirus infection (OR 1.41, 95% CI 0.46-4.36, p=0.57). Nonsecretors were as likely to develop symptomatic norovirus gastroenteritis as secretors (OR 1.41), demonstrating a secretor-independent susceptibility pattern in this GI.3 outbreak.
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