Key result
Novel LUX real-time PCR detects ~20% more norovirus-positive stool specimens than conventional PCR.
Why the study?
Do novel LUX real-time PCR assays accurately detect and quantify norovirus in clinical stool specimens compared to established methods?
Population
103 clinical stool specimens from Sweden and Nicaragua, and 11 coded control specimens in a reference panel
Comparison
Two novel light-upon-extension real-time PCR… vs Conventional PCR and TaqMan real-time PCR
Authors
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May support higher-sensitivity norovirus detection in stool; leaves open clinical validation before routine adoption.
Observational (n=103)
Yes
Do novel LUX real-time PCR assays accurately detect and quantify norovirus in clinical stool specimens compared to established methods?
Absolute Event Rate: 45.6% vs 37.9%
The novel LUX real-time PCR assay provides a specific and cost-effective method for detecting and quantifying norovirus in clinical specimens, outperforming conventional PCR.
Nordgren et al. (2007) conducted an observational in Norovirus (n=103). Light-upon-extension (LUX) real-time PCR assays vs. Conventional PCR was evaluated on Detection of norovirus positive stool specimens. The novel LUX real-time PCR assay detected more norovirus-positive clinical stool specimens (45.6%) compared to conventional PCR (37.9%).
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