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This review aims to clarify the role of TGF-β in chronic wound healing, particularly from the perspective of keratinocyte function.

January 28, 2020CellsOpen Access

Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective

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Review reveals TGF-β's complex role in chronic wound healing, focusing on keratinocyte activity.

This review aims to clarify the role of TGF-β in chronic wound healing, particularly from the perspective of keratinocyte function.
Compilation of existing evidence on TGF-β and chronic wounds
Focus on keratinocyte responses during skin healing
Discussion on the limitations and future directions of TGF-β research
Elevated TGF-β levels are observed in the epidermis of chronic wounds
Previous beliefs of low TGF-β levels in these wounds are challenged
TGF-β's context-dependent signaling is emphasized in its role in healing.

Liarte et al. (2020) studied this question.

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