Key result
Elevated cardiac troponin I (≥0.3 ng/mL) after aneurysmal subarachnoid hemorrhage was associated with early ejection fraction <50% (44% vs 5%, P<0.0001) and regional wall motion abnormalities.
Why the study?
Is elevated cardiac troponin I associated with persistent electrocardiographic and echocardiographic abnormalities in patients with aneurysmal subarachnoid hemorrhage?
Population
204 patients with aneurysmal subarachnoid hemorrhage (aSAH) with Fisher grade >=2 and/or Hunt/Hess grade >=3
Comparison
Elevated cardiac troponin I vs Peak cTnI <0.3 ng/mL
Design
Cohort
Follow-up
Up to 12 days
Authors
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May identify subarachnoid hemorrhage patients for echocardiography; leaves open whether troponin monitoring improves outcomes.
Cohort (n=204)
Is elevated cardiac troponin I associated with persistent electrocardiographic and echocardiographic abnormalities in patients with aneurysmal subarachnoid hemorrhage?
Absolute Event Rate: 44% vs 5%
p-value: p=<0.0001
Elevated cardiac troponin I after aneurysmal subarachnoid hemorrhage is associated with persistent QTc prolongation, ventricular arrhythmias, and left ventricular dysfunction.
Hravnak et al. (2009) conducted a cohort in Aneurysmal subarachnoid hemorrhage (n=204). Elevated cardiac troponin I (≥0.3 ng/mL) vs. Cardiac troponin I <0.3 ng/mL was evaluated on Early ejection fraction <50% (p=<0.0001). Elevated cardiac troponin I (≥0.3 ng/mL) after aneurysmal subarachnoid hemorrhage was associated with early ejection fraction <50% (44% vs 5%, P<0.0001) and regional wall motion abnormalities.
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