Thermodynamic Uncertainty Relation for Arbitrary Initial States

The thermodynamic uncertainty relation (TUR) describes a trade-off relation between nonequilibrium currents and entropy production and serves as a fundamental principle of nonequilibrium thermodynamics. However, currently known TURs presuppose either specific initial states or an infinite-time average, which severely limits the range of applicability. Here we derive a finite-time TUR valid for arbitrary initial states from the Cramér-Rao inequality. We find that the variance of an accumulated current is bounded from below by the instantaneous current at the final time, which suggests that "the boundary is constrained by the bulk". We apply our results to feedback-controlled processes and successfully explain a recent experiment which reports a violation of a modified TUR with feedback control. We also derive a TUR that is linear in the total entropy production and valid for discrete-time Markov chains with nonsteady initial states. The obtained bound exponentially improves the existing bounds in a discrete-time regime.