October 27, 2003Current Opinion in Cardiology
Prediction of sites of coronary atherosclerosis progression:In vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior
Key result
In vivo profiling of endothelial shear stress and vascular wall morphology can characterize the local hemodynamic environment and may predict focal areas of atherosclerosis progression.
Why the study?
Can in vivo profiling of endothelial shear stress and vascular wall morphology predict the progression of coronary atherosclerosis?
Population
Patients with or at risk for coronary atherosclerosis and in-stent restenosis
Design
Review
Authors
Discussion
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Implication
May refine coronary risk stratification in research; leaves open prospective validation before any clinical use.
Structured PICO
Can in vivo profiling of endothelial shear stress and vascular wall morphology predict the progression of coronary atherosclerosis?
P
Population
Patients with or at risk for coronary atherosclerosis and in-stent restenosis
E
Exposure
In vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics
O
Outcome
Prediction of focal areas of atherosclerosis progressionsurrogate
In vivo profiling of endothelial shear stress and vascular wall morphology may allow for the prediction of focal coronary atherosclerosis progression, potentially guiding preemptive interventions.
Limitations
- Future studies need to identify the factors responsible for vulnerable plaque formation.
Cite This Study
Stone et al. (2003) conducted a review in Coronary atherosclerosis progression. In vivo profiling of endothelial shear stress and arterial wall characteristics was evaluated. In vivo profiling of endothelial shear stress and vascular wall morphology can characterize the local hemodynamic environment and may predict focal areas of atherosclerosis progression.