Key result
Baseline grade 3 diastolic dysfunction predicts ~173% higher 1-year CV death or rehospitalization after TAVR.
Why the study?
Few studies have evaluated whether diastolic function could predict clinical outcomes in patients with aortic stenosis undergoing TAVR.
Does baseline diastolic dysfunction grade predict cardiovascular death or rehospitalization in patients with aortic stenosis undergoing TAVR?
Population
1,750 patients with aortic stenosis undergoing TAVR in the PARTNER 2 SAPIEN 3 registry
Comparison
Baseline and 30-day post-TAVR diastolic dysfunction grades
Design
Registry-based cohort study
Follow-up
2 years
Authors
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May refine post-TAVR risk stratification; leaves open whether diastolic assessment should guide management.
Cohort (n=1,750)
Yes
Does baseline diastolic dysfunction grade predict cardiovascular death or rehospitalization in patients with aortic stenosis undergoing TAVR?
Hazard Ratio: 2.73 (95% CI 1.07–6.98)
p-value: p=0.04
Baseline severe diastolic dysfunction and lack of early improvement in diastolic function are significant predictors of adverse clinical outcomes following TAVR.
Ong et al. (2020) conducted a cohort in Aortic stenosis (n=1,750). Diastolic dysfunction vs. Lower grades of diastolic dysfunction was evaluated on 1-year cardiovascular death or rehospitalization (HR 2.73, 95% CI 1.07-6.98, p=0.04). Baseline grade 3 diastolic dysfunction predicted 1-year cardiovascular death or rehospitalization (HR 2.73; 95% CI 1.07-6.98; P=0.04) in patients undergoing TAVR.
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