Cardiovascular magnetic resonance measurement of aortic valve opening slope was significantly associated with plasma NT-pro-BNP levels in patients with aortic stenosis (r = -0.36, P = 0.002).
Observational (n=79)
Is cardiovascular magnetic resonance imaging feasible and reproducible for evaluating aortic valve kinetics, and do these parameters correlate with prognostic markers in aortic stenosis?
CMR is a feasible and reproducible modality for assessing aortic valve opening and closing kinetics, which correlate with NT-proBNP levels in patients with aortic stenosis.
Effect estimate: r = -0.36
p-value: p=0.002
AIMS: The aims of this study were : (i) to determine the feasibility and reproducibility of the measurement of valve kinetic parameters by cardiovascular magnetic resonance (CMR) and (ii) to examine the association between these parameters and markers of a poor prognosis in patients with aortic stenosis (AS). METHODS AND RESULTS: Eight healthy control subjects and 71 patients with AS (0.60 cm(2) ≤ EOA ≤ 1.90 cm(2)) underwent transthoracic echocardiography (TTE) and CMR. The valve opening slope (OS) and closing slope (CS) were calculated from instantaneous effective orifice area (EOA) curves obtained by CMR. Intra- and inter-observer variability were 4.8 ± 3.9 and 5.0 ± 4.1%, respectively, for OS, 3.8 ± 2.9 and 4.0 ± 3.1% for CS. OS was significantly related to the plasma level of NT-pro-brain natriuretic peptide (BNP) (r = -0.36, P = 0.002), whereas the EOA or gradient were not. CONCLUSION: This study demonstrates the excellent feasibility and reproducibility of CMR for the measurement of valve kinetic parameters in patients with AS. Larger studies are needed to confirm the incremental prognostic value of these new CMR parameters of aortic valve kinetics in patients with severe AS.
García et al. (Tue,) conducted a observational in Aortic stenosis (n=79). Cardiovascular magnetic resonance (CMR) was evaluated on Association between valve opening slope (OS) and plasma NT-pro-BNP (r = -0.36, p=0.002). Cardiovascular magnetic resonance measurement of aortic valve opening slope was significantly associated with plasma NT-pro-BNP levels in patients with aortic stenosis (r = -0.36, P = 0.002).