Key result
SSRI non-responders experienced significantly more unwanted psychological side effects than responders (p=0.009) and cited them as the primary reason for quitting treatment.
Why the study?
Do psychological side effects influence the decision to quit serotonin reuptake inhibitor therapy in adults with depression?
Population
161 adults who had completed a course of treatment for depression with a serotonin reuptake inhibitor (SSRI)
Design
Cross-sectional
Authors
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Psychological side effects may influence SSRI discontinuation in non-responders; hypothesis-generating for prospective adherence trials in depression.
Cross-Sectional (n=161)
Do psychological side effects influence the decision to quit serotonin reuptake inhibitor therapy in adults with depression?
p-value: p=0.009
Psychological side effects are a significant factor in patients' decisions to discontinue SSRI therapy for depression and should be included in clinical discussions.
Bolling et al. (2004) conducted a cross-sectional in Depression (n=161). Serotonin reuptake inhibitors (SSRIs) was evaluated on Unwanted psychological effects and reasons for quitting SSRI treatment (p=0.009). SSRI non-responders experienced significantly more unwanted psychological side effects than responders (p=0.009) and cited them as the primary reason for quitting treatment.
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