Key result
An Adherence Score based on 19 methodological factors was developed to objectively evaluate the quality of brachial artery Flow Mediated Dilation studies, with higher scores relating to better reproducibility.
Provides a 19-item scoring tool to objectively assess adherence to expert guidelines in brachial artery Flow Mediated Dilation studies, which correlates with data reproducibility.
May guide inclusion of reliable FMD studies in meta-analyses; extends guidelines into an objective scoring framework for investigators.
Brachial artery Flow Mediated Dilation (FMD) is widely used as a non-invasive measure of endothelial function. Adherence to expert consensus guidelines on FMD measurement has been found to be of vital importance to obtain reproducible data. This article lists the literature data which was considered in the development of a tool to aid in the objective judgement of the extent to which published studies adhered to expert guidelines for FMD measurement. Application of this tool in a systematic review of FMD studies (http://dx.doi.org/10.1016/j.atherosclerosis.2016.03.011) (Greyling et al., 2016 [1]) indicated that adherence to expert consensus guidelines is strongly correlated to the reproducibility of FMD data.
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Greyling et al. (2016) studied Endothelial function (FMD measurement) (n=33). Adherence Score tool was evaluated on Development of an Adherence Score for FMD studies. An Adherence Score based on 19 methodological factors was developed to objectively evaluate the quality of brachial artery Flow Mediated Dilation studies, with higher scores relating to better reproducibility.
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