A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet (X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation.
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Wang et al. (2019) studied this question.
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