Triphosphonium salt-catalyzed direct synthesis of α‑2-deoxyglycosides

An efficient, triphosphonium salt-catalyzed method for 2-deoxyglycosylation has been developed using glycosyl hemiacetals. This method uses mild protocols, proceeds at room temperature, and is completed within 4 h, yielding 2-deoxyglycosides in 64–96% yields and α/β ratios exceeding 20:1. The method demonstrates broad compatibility with various glycosyl donors and acceptors, underscoring its potential in glycosylation chemistry.