Commentary critiques methodological limitations in the evaluation of OAB in rheumatoid arthritis patients, suggesting further research is needed.
We read with interest the study by Cirakoglu and Yuce on overactive bladder (OAB) and central sensitization (CS) in rheumatoid arthritis (RA) patients. While the study provides valuable hypothesis‑generating insights, several methodological limitations warrant consideration. The OAB-V8 cut‑off of 8 was validated in a primary care population, not in RA patients, and dichotomising this ordinal scale discards information and reduces statistical power. The regression model included correlated variables (HAQ-DI, VAS-pain, DAS-28) without testing for multicollinearity, which can inflate standard errors and produce unreliable p‑values. Additionally, the authors did not verify key logistic regression assumptions, including linearity of continuous variables with the logit and absence of influential outliers. These limitations suggest that the findings should be interpreted as hypothesis‑generating rather than definitive. Future studies should address these methodological issues to clarify the relationship between CS and OAB in RA.
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Marhabo et al. (2026) studied this question.
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