Aging, Genetic Susceptibility and Risk of Chronic Inflammatory Upper Airway Diseases: Finding From A Prospective Cohort Study

Key Points

• The research aims to explore the relationship between biological aging and the risk of chronic inflammatory upper airway diseases.
• Used a prospective cohort design to assess the effects of PhenoAge acceleration.
• Examined incident cases of chronic rhinosinusitis with and without nasal polyps.
• PhenoAge acceleration linked to an increase in chronic rhinosinusitis with and without nasal polyps.
• Biological aging mediates 19.5% of smoking effects on chronic rhinosinusitis without nasal polyps and 26.4% for chronic rhinosinusitis with nasal polyps.