Key result
Higher BMI in premenopausal women is linked to worsening insulin resistance and hepatic metabolic markers.
Why the study?
Does the degree of obesity correlate with worsening metabolic and hormonal disturbances in premenopausal women?
Observational (n=352)
Does the degree of obesity correlate with worsening metabolic and hormonal disturbances in premenopausal women?
Answers are grounded in this paper and cite their sources.
In premenopausal women, increasing obesity severity is associated with early markers of metabolic dysfunction including insulin resistance, hepatic disturbances, and elevated uric acid, but not necessarily lipid or blood pressure changes.
Background The current obesity epidemic inevitably affects the health of patients and leads to a deterioration in their quality of life. According to scientific literature, obesity per se leads to multiple metabolic abnormalities. However, it is still not clarified what the precise interrelations between the degree of obesity and the presence of various metabolic and hormonal disturbances are, especially in women. Objective The present study aimed to compare the differences in metabolic parameters between premenopausal women with overweight and obesity, thus evaluating the role of obesity in the occurrence of metabolic imbalance. Materials and methods We conducted a retrospective study of a total of 352 overweight and obese patients (18-50 years) with a body mass index (BMI) ≥ 25 kg/m 2 . The obesity classification of the selected cohort of patients was based on the WHO criteria for BMI. Clinical, anthropometric, and metabolic parameters were extracted from the medical records and analyzed. Results In the investigated women, BMI increase correlated significantly with higher levels of uric acid (p = 0.019) and alanine aminotransferase (p = 0.015), as well as with elevated fasting insulin levels and insulin resistance index (p<0.001). Conversely, lipid profile parameters, prevalence of carbohydrate abnonrialities, and hypertension did not differ between patients with slight, moderate, and severe obesity (p>0.05). Patients with severe obesity had slightly higher TSH levels (2.8 vs. 2.5 mIU/L, p = 0.041), and significantly increased fatty liver index (p<0.001) compared to leaner women. Conclusions The increase of fat mass deposition in premenopausal women is associated mainly with enhanced insulin resistance, hepatic disturbances, and uric acid elevation, which could be the earliest markers of metabolic dysfunction. Screening and monitoring of metabolic parameters in obese pre-menopausal women is essential for the prevention of further health complications.
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Gavrailova et al. (2026) conducted an observational in Overweight and obesity (n=352). Increasing BMI / degree of obesity vs. Lower BMI / slight obesity was evaluated on Metabolic parameters (uric acid, ALT, insulin resistance) (p=<0.001).
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