Key result
Serum uric acid levels were significantly higher in metabolically unhealthy obese women compared to metabolically healthy obese women (5.0 vs 4.5 mg/dL, p=0.001).
Cross-Sectional (n=193)
No
Absolute Event Rate: 5% vs 4.5%
p-value: p=0.001
Uric acid levels are significantly elevated in metabolically unhealthy obese women compared to metabolically healthy obese women, suggesting its utility as an accessible marker for metabolic syndrome and cardiovascular risk.
May support uric acid as a marker in obese women; hypothesis-generating and requires prospective validation before clinical use.
Objective: In this study, we aimed to investigate the difference of uric acid levels between metabolically healthy and unhealthy obese individuals.Methods: Patients of internal medicine and endocrinology outpatient clinics who admitted with the complaint of overweight were separated into two groups, by diagnostic criteria for metabolic syndrome, as metabolically healthy obese and metabolically unhealthy obese individuals.Total of 193 women aged between 18 to 70 years were enrolled into study.Results: Statistically significant differences were determined regarding waist circumference (p=0.038),HOMA-IR (p<0.001) and uric acid levels (p=0.001) between metabolically healthy obese and metabolically unhealthy obese patients while high-sensitive CRP levels (p>0.05) were not differ between these groups.When patients were separated into two groups according to uric acid median, the rate of metabolic syndrome found to be increased in high uric acid group (p=0.021).A correlation analysis showed that uric acid was significantly associated with number of metabolic syndrome parameters (r=0.270,p<0.001) beyond presence of metabolic syndrome. Conclusion:In the fact of determined relation of uric acid with the insulin resistance and significant difference of uric acid levels between metabolically healthy and nonhealthy obese groups, uric acid can be considered as a cheap, accessible and sensitive parameter for metabolic syndrome and cardiovascular risk factor in obese individuals.
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A 2014 study conducted a cross-sectional in Obesity (n=193). Metabolically unhealthy obesity vs. Metabolically healthy obesity was evaluated on Serum uric acid levels (mg/dL) (p=0.001). Serum uric acid levels were significantly higher in metabolically unhealthy obese women compared to metabolically healthy obese women (5.0 vs 4.5 mg/dL, p=0.001).
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