Case report demonstrates diagnostic value of mNGS, culture, and antigen testing for cryptococcosis in non-HIV patients, indicating challenges in diagnosis.
Key Points
This case report aims to illustrate the diagnosis of disseminated cryptococcosis in a non-HIV patient using various diagnostic methods.
Case report of a 72-year-old male post-cardiac surgery with disseminated cryptococcosis.
Integrated diagnostic approach using metagenomic next-generation sequencing, culture, and antigen testing.
Patient received liposomal amphotericin B and flucytosine antifungal treatment.
Cryptococcus neoformans was identified using mNGS with 8 sequence reads and cultured from blood, urine, and pleural effusion.