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September 4, 2019Anesthesia & Analgesia77 citations

Arterial Catheters for Early Detection and Treatment of Hypotension During Major Noncardiac Surgery: A Randomized Trial

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ANAmanda J. NaylorDSDaniel I. SesslerKMKamal Maheshwari

Key Result

Continuous invasive arterial pressure monitoring increased detection of AUC-MAP <65 mm Hg compared to oscillometric monitoring (OR 1.78; 95% CI 1.18-2.70; P=0.006).

Study Design

Type

RCT (n=306)

Structured PICO

Does continuous invasive arterial pressure monitoring reduce AUC-MAP <65 mm Hg compared to intermittent oscillometric monitoring in adults having noncardiac surgery?

P
Population
306 adults undergoing noncardiac surgery.
I
Intervention
Continuous invasive arterial pressure monitoring via arterial catheter (pressures recorded at 1-minute intervals)
C
Comparator
Intermittent oscillometric blood pressure monitoring (pressures typically recorded at 5-minute intervals)
O
Outcome
Area under the curve (AUC) mean arterial pressure (MAP) <65 mm Hgsurrogate

Continuous invasive arterial pressure monitoring during noncardiac surgery detects significantly more hypotension compared to intermittent oscillometric monitoring.

Main Result

Odds Ratio: 1.78 (95% CI 1.18–2.7)

p-value: p=0.006

Abstract

BACKGROUND: Continuous blood pressure monitoring may facilitate early detection and prompt treatment of hypotension. We tested the hypothesis that area under the curve (AUC) mean arterial pressure (MAP) 91 mm Hg × minutes of AUC-MAP <65 mm Hg (ie, no hypotension and 3 equally sized groups of increasing hypotension). RESULTS: One hundred fifty-two patients were randomly assigned to arterial catheter use and 154 to oscillometric monitoring. For various clinical reasons, 143 patients received an arterial catheter, while 163 were monitored oscillometrically. There were a median Q1, Q3 of 246 187, 308 pressure measurements in patients with arterial catheters versus 55 (46, 75) measurements in patients monitored oscillometrically. In the primary intent-to-treat analysis, catheter-based monitoring increased detection of AUC-MAP <65 mm Hg, with an estimated proportional odds ratio (ie, odds of being in a worse hypotension category) of 1.78 (95% confidence interval CI, 1.18-2.70; P = .006). The result was robust over an as-treated analysis and for sensitivity analyses with thresholds of 60 and 70 mm Hg. CONCLUSIONS: Intraoperative blood pressure monitoring with arterial catheters detected nearly twice as much hypotension as oscillometric measurements.

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Cite This Study

Naylor et al. (2019) conducted an RCT in Major noncardiac surgery (n=306). Continuous invasive arterial pressure monitoring vs. Intermittent oscillometric blood pressure monitoring was evaluated on Area under the curve (AUC) mean arterial pressure (MAP) <65 mm Hg (OR 1.78, 95% CI 1.18-2.70, p=0.006). Continuous invasive arterial pressure monitoring increased detection of AUC-MAP <65 mm Hg compared to oscillometric monitoring (OR 1.78; 95% CI 1.18-2.70; P=0.006).

synapsesocial.com/papers/6a338c05564550b2400e745dhttps://doi.org/10.1213/ane.0000000000004370
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