A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

Yuqing Hu; Qiu-Lian Hao; Xiaohang Wang; Xin-Rong Li; Zixuan Xu; Lu-Lu Sun; Tianlin Ni; Xianzhi Chai; Hai‐Hao Han; Junji Zhang

doi:10.1039/d6cc02864k

January 1, 2026Chemical Communications

A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

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Key Points

The aim is to develop and utilize a selective probe for the detection of peroxynitrite in the brains of epileptic mice.
Developed a ratiometric near-infrared fluorescent probe CCy7-DP for peroxynitrite detection.
Utilized a selective addition-elimination reaction to trigger electron rearrangement.
Conducted imaging studies in the brains of epileptic mice.
The probe demonstrated high selectivity and sensitivity to peroxynitrite levels in the brain.
Successful imaging of peroxynitrite in the brains of epileptic mice was achieved.
The findings indicate potential for further understanding neurological disorders related to oxidative stress.

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Implication

Ratiometric probe reveals peroxynitrite levels in epileptic mice, indicating potential for neurological research.

Abstract

A ratiometric near-infrared probe CCy7-DP was developed for peroxynitrite detection, utilizing a highly selective additionelimination reaction between ONOO -and diphenyl phosphinate. This reaction triggered an electron rearrangement of the cyanine...

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Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a338c31630953a74978d889 https://doi.org/10.1039/d6cc02864k

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A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

Key Points

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Abstract

Discussion

Cite This Study

A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

Key Points

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Implication

Abstract

Discussion

Cite This Study

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