Key result
Propensity matching successfully created a cohort of 1,057 children with single, multiple, or no early anesthesia exposures who demonstrated only slight differences in baseline characteristics, enabling future neurodevelopmental analyses.
Why the study?
Does exposure to general anesthesia prior to age 3 years increase the risk of adverse neurodevelopmental outcomes in children?
Population
1,057 children born in Olmsted County, MN from January 1, 1996 to December 31, 2000, enrolled in the local…
Comparison
General anesthesia exposure prior to age 3 years vs No exposure to general anesthesia prior to age 3…
Design
Cohort
Authors
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Supports planned neurodevelopmental analyses of early anesthesia exposure; leaves open any clinical implications pending outcome data.
Cohort (n=1,057)
Does exposure to general anesthesia prior to age 3 years increase the risk of adverse neurodevelopmental outcomes in children?
A population-based propensity-matched cohort of 1,057 children was successfully constructed to study the neurodevelopmental effects of early childhood anesthesia exposure, minimizing confounding factors.
Hu et al. (2016) conducted a cohort in Anesthesia exposure in early childhood (n=1,057). General anesthesia exposure before age 3 vs. No anesthesia exposure before age 3 was evaluated on Differences in baseline characteristics (birth, parental, comorbidities, socioeconomic status) among propensity-matched exposure groups. Propensity matching successfully created a cohort of 1,057 children with single, multiple, or no early anesthesia exposures who demonstrated only slight differences in baseline characteristics, enabling future neurodevelopmental analyses.
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