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June 18, 2026International Journal of Biological MacromoleculesOpen Access

3D printing of alginate scaffolds for low-pH environments through slow alginic-acid hydrogel formation

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Authors

YRYahya RharbiARAhlem RomdhaneDBDidier Blésès

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Overview

Randomized trial demonstrates scaffold formation in acidic environments, guiding future biomaterial applications.

Key Points

  • This study aims to develop a method for 3D printing alginate scaffolds that maintain structural integrity in low-pH environments.
  • Used a two-step reactive-printing strategy to create alginate bioink prepared in acidic conditions.
  • Characterized rheological properties of the bioink to optimize extrusion and scaffold shape fidelity.
  • Mixed aged alginic-acid pregel with calcium carbonate for ionic crosslinking after deposition.
  • Printed alginate scaffolds achieved a significant increase in storage modulus, from approximately 1 to over 20 kPa.
  • Effective decoupling of shaping and reinforcement allowed for stable structures under acidic conditions.
  • The processing window for extrusion was tunable based on GDL concentration and aging time.

Cite This Study

Rharbi et al. (2026) studied this question.

synapsesocial.com/papers/6a338cf6630953a74978e1f8https://doi.org/10.1016/j.ijbiomac.2026.153041
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Also Consider

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  1. 1Rheological Properties and Printability of Alginate Hydrogel Inks for Extrusion‐Based <scp>3D</scp> Printing2026
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