Radical-promoted “unstrained” C–C and C–N bond cleavage: a blueprint for deconstructive skeletal editing

Q: What does this research mean for the field?

A two-step framework utilizing alkoxy radicals enables the cleavage of unstrained C–C and C–N bonds for deconstructive skeletal editing by separating radical generation from the divergent reactivity of the resulting carbon-centered radical. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

José Justicia; Sara P. Morcillo

doi:10.1039/d5cs01539a

January 1, 2026Chemical Society ReviewsOpen Access

Radical-promoted “unstrained” C–C and C–N bond cleavage: a blueprint for deconstructive skeletal editing

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Key Points

The study aims to explore radical-promoted cleavage methods for C–C and C–N bonds as part of skeletal editing.
Utilization of alkoxy radicals in a two-step framework
Separation of radical generation from reactivity
Focus on β-scission-derived carbon-centred radicals
Successful cleavage of C–C and C–N bonds via the radical method
Demonstrated divergent reactivity in skeletal editing
Established a blueprint for future synthetic applications

Implication

Radical promotion cleaves C–C and C–N bonds in skeletal editing, indicating a novel synthetic pathway.

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Cite This Study

Justicia et al. (2026) studied this question.

synapsesocial.com/papers/6a338d85630953a74978e76c https://doi.org/10.1039/d5cs01539a

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Radical-promoted “unstrained” C–C and C–N bond cleavage: a blueprint for deconstructive skeletal editing

Key Points

Implication

Discussion

Cite This Study

Radical-promoted “unstrained” C–C and C–N bond cleavage: a blueprint for deconstructive skeletal editing

Key Points

Implication

Discussion

Cite This Study

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