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June 1, 2026The Quarterly Journal of Nuclear Medicine and Molecular Imaging

Evidence-based PET in cardiovascular infectious diseases: an umbrella review

Domenico ALBANO Slavko Tasevski Stefano PANAREO

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Key Points

To evaluate the diagnostic accuracy of FDG PET/CT for various cardiovascular infections including endocarditis.
Systematic review of systematic reviews following a predefined protocol.
Literature search conducted until October 2025.
Quality assessment performed on eligible systematic reviews.
FDG PET/CT shows good diagnostic accuracy for prosthetic valve endocarditis, CIED, and LVAD infections.
Accuracy of FDG PET/CT is suboptimal for patients with native valve endocarditis.

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Implication

Umbrella review finds FDG PET/CT accurately detects various cardiovascular infections, suggesting a valuable diagnostic tool.

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Cite This Study

ALBANO et al. (2026) studied this question.

synapsesocial.com/papers/6a338e14630953a74978ed44 https://doi.org/10.23736/s1824-4785.26.03714-3

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Evidence‐Based Data on the Diagnostic Role and Clinical Usefulness of [ <sup>18</sup> F]FDG PET/CT in Endocarditis and Cardiac Device Infectionsreview · 2024 · 5 citations
218F-FDG PET/CT in Infective Endocarditis: Indications and Approaches for Standardizationreview · 2021 · 81 citations
3The role of 18F-FDG PET/CT in infectious endocarditis: a systematic review and meta- analysismeta-analysis · 2016 · 37 citations
4Contemporary Role of Positron Emission Tomography (PET) in Endocarditis: A Narrative Reviewreview · 2024 · 16 citations
518F- FDG PET/CT in reclassifying the probable diagnosis of IE - A reviewreview · 2024 · 4 citations

The Role of 18FDG PET/CT in the Assessment of Endocarditis, Myocarditis and Pericarditis2020
Role of 18F-FDG PET/CT in infection of cardiovascular implantable electronic devices2019
18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS2024
Shaping the role of FDG PET in bladder cancer: current evidence and ongoing clinical trialThe Quarterly Journal of Nuclear Medicine and Molecular Imaging · 2026
Evidence-based role of PET imaging in cardiac and systemic sarcoidosis: an umbrella review of the current literatureThe Quarterly Journal of Nuclear Medicine and Molecular Imaging · 2026

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