Fibrotic-like collagen matrices as 3D in vitro models for investigating the impact of pathological extracellular matrix on skeletal muscle cell behavior

Marie Camman; Naomi Nieswic; Maxime Mauviel; Pierre Joanne; Julie Brun; Lena Villerabel; Alba Marcellan; Onnik Agbulut; Christophe Hélary

doi:10.1039/d6bm00046k

January 1, 2026Biomaterials Science

Fibrotic-like collagen matrices as 3D in vitro models for investigating the impact of pathological extracellular matrix on skeletal muscle cell behavior

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Key Points

This research aims to explore how fibrotic-like collagen matrices influence skeletal muscle cell behavior.
Developed fibrotic-like collagen matrices as 3D in vitro models.
Assessed the behavior of skeletal muscle cells within these matrices under various conditions.
Evaluated cell proliferation and differentiation in response to the pathological ECM.
Skeletal muscle cells showed altered proliferation rates when cultured on fibrotic matrices compared to normal matrices.
Differentiation markers were significantly reduced in the presence of pathological ECM, indicating impaired muscle cell functionality.

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Implication

Investigates ECM impact on muscle cell behavior using 3D collagen models, suggesting new therapeutic approaches.

Abstract

Skeletal muscle fibrosis is a hallmark of muscular dystrophies, aging or severe muscle injuries. It is characterized by the extensive accumulation of extracellular matrix (ECM), primarily composed of type I...

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Camman et al. (2026) studied this question.

synapsesocial.com/papers/6a338e6e630953a74978efcd https://doi.org/10.1039/d6bm00046k

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Fibrotic-like collagen matrices as 3D in vitro models for investigating the impact of pathological extracellular matrix on skeletal muscle cell behavior

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Fibrotic-like collagen matrices as 3D in vitro models for investigating the impact of pathological extracellular matrix on skeletal muscle cell behavior

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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