Key result
Confined compression of oligomeric type I collagen matrices recapitulated hallmarks of cardiac fibrosis, including increased collagen content and strong beating abrogation in seeded cardiomyocytes.
Why the study?
Does confined compression of type I collagen matrices create a viable in vitro model for cardiac fibrosis?
Does confined compression of type I collagen matrices create a viable in vitro model for cardiac fibrosis?
Confined compression of type I collagen matrices provides a promising in vitro heart-on-chip model to study cardiac fibrosis.
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Offers a new in vitro platform for cardiac fibrosis studies; leaves open validation in human cells and therapeutic translation.
Worke et al. (2017) studied Cardiac fibrosis. Confined compression of oligomeric, type I collagen matrices was evaluated. Confined compression of oligomeric type I collagen matrices recapitulated hallmarks of cardiac fibrosis, including increased collagen content and strong beating abrogation in seeded cardiomyocytes.
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