Key result
Cervical transcutaneous vagal nerve stimulation significantly improved objective arousal (p=0.024), multitasking performance, and reduced subjective fatigue compared to sham stimulation during 34 hours of sustained wakefulness.
Why the study?
Common pharmacological fatigue countermeasures have limited effectiveness, prompting the investigation of non-invasive neuromodulation techniques like cervical transcutaneous vagal nerve stimulation to mitigate the negative effects of fatigue on cognition and mood.
Does cervical transcutaneous vagal nerve stimulation (ctVNS) improve cognitive performance and reduce fatigue in healthy adults under sleep deprivation stress?
RCT (n=40)
Double-blind
Randomized
No
Does cervical transcutaneous vagal nerve stimulation (ctVNS) improve cognitive performance and reduce fatigue in healthy adults under sleep deprivation stress?
Cervical transcutaneous vagal nerve stimulation (ctVNS) effectively mitigates cognitive performance decrements and subjective fatigue during sustained sleep deprivation in healthy adults.
ctVNS may reduce fatigue during prolonged wakefulness; hypothesis-generating and leaves open efficacy in larger trials.
Fatigue is a pervasive public health and safety issue. Common fatigue countermeasures include caffeine or other chemical stimulants. These can be effective in limited circumstances but other non-pharmacological fatigue countermeasures such as non-invasive electrical neuromodulation have shown promise. It is reasonable to suspect that other types of non-invasive neuromodulation may be similarly effective or perhaps even superior. The objective of this research was to evaluate the efficacy of cervical transcutaneous vagal nerve stimulation (ctVNS) to mitigate the negative effects of fatigue on cognition and mood. Two groups (active or sham stimulation) of twenty participants in each group completed 34 h of sustained wakefulness. The ctVNS group performed significantly better on arousal, multi-tasking, and reported significantly lower fatigue ratings compared to sham for the duration of the study. CtVNS could be a powerful fatigue countermeasure tool that is easy to administer, long-lasting, and has fewer side-effects compared to common pharmacological interventions.
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McIntire et al. (2021) conducted an RCT in Sleep deprivation stress and fatigue (n=40). Cervical transcutaneous vagal nerve stimulation (ctVNS) vs. Sham stimulation was evaluated on Psychomotor vigilance task (PVT) a' metric (arousal) (p=0.024). Cervical transcutaneous vagal nerve stimulation significantly improved objective arousal (p=0.024), multitasking performance, and reduced subjective fatigue compared to sham stimulation during 34 hours of sustained wakefulness.
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