Key result
Non-paroxysmal atrial fibrillation was associated with higher all-cause mortality than paroxysmal AF (P=0.0018), but was not an independent predictor of death after multivariable adjustment.
Why the study?
Does non-paroxysmal atrial fibrillation increase the risk of mortality and stroke compared to paroxysmal atrial fibrillation in a real-world European cohort?
Observational (n=2,589)
Yes
Does non-paroxysmal atrial fibrillation increase the risk of mortality and stroke compared to paroxysmal atrial fibrillation in a real-world European cohort?
p-value: p=0.0018
In a real-world European registry, the higher unadjusted mortality observed in non-paroxysmal versus paroxysmal atrial fibrillation is driven by a more severe baseline clinical profile rather than the AF pattern itself.
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Comorbidities, not AF pattern, drive excess mortality; leaves open whether rhythm strategies improve survival after adjustment.
Boriani et al. (2016) conducted an observational in Atrial fibrillation (n=2,589). Non-paroxysmal atrial fibrillation vs. Paroxysmal atrial fibrillation was evaluated on All-cause mortality (p=0.0018). Non-paroxysmal atrial fibrillation was associated with higher all-cause mortality than paroxysmal AF (P=0.0018), but was not an independent predictor of death after multivariable adjustment.
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