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The research aims to develop effective therapeutics using nanobodies to neutralize SARS-CoV-2.

November 5, 2020ScienceOpen Access

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

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The research aims to develop effective therapeutics using nanobodies to neutralize SARS-CoV-2.
Identified potent nanobodies through camelid immunization and proteomics.
Engineered multivalent nanobody constructs with high neutralization potency.
Utilized structural proteomics and modeling to analyze binding interactions.
Identified nanobodies with affinities ranging from picomolar to femtomolar (IC50 as low as 0.058 ng/ml).
Multiple distinct epitopes were revealed, indicating various neutralization mechanisms.
The nanobodies demonstrated stability against lyophilization and aerosolization.

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Randomized trial demonstrates high neutralization efficacy of multivalent nanobodies against SARS-CoV-2, suggesting a promising therapeutic approach.

Xiang et al. (2020) studied this question.

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Randomized trial demonstrates high neutralization efficacy of multivalent nanobodies against SARS-CoV-2, suggesting a promising therapeutic approach.