Metabolic syndrome significantly increased the risk of mortality among nondiabetic patients with stable coronary artery disease (RR 3.5; 95% CI 1.1-6; P=0.03).
Cohort
Does the presence of metabolic syndrome increase mortality in patients with symptomatic chronic multivessel coronary artery disease?
Metabolic syndrome is strongly associated with increased 2-year mortality in patients with stable multivessel coronary artery disease, providing prognostic value independent of diabetes status.
Relative Risk: 3.5 (95% CI 1.1–6)
p-value: p=0.03
OBJECTIVE: We characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. METHODS: Patients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome. RESULTS: The criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P<0.05), glucose intolerance (P=0.007), and diabetes (P=0.04) was associated with an increased mortality in our studied population. Moreover, despite a clear tendency for each of its components to increase the mortality risk, only the presence of the MetS significantly increased the risk of mortality among nondiabetic study participants in a multivariate model (P=0.03, relative risk 3.5, 95% confidence interval 1.1-6). Finally, MetS was still associated with increased mortality even after adjustment for diabetes status. These results indicate a strong and consistent relationship of the MetS with mortality in patients with stable coronary artery disease. CONCLUSION: Although glucose homeostasis seems to be the major force driving the increased risk of MetS, the operational diagnosis of MetS still has information for stratifying patients when diabetes information is taken into account.
Lopes et al. (Mon,) conducted a cohort in symptomatic chronic multivessel coronary artery disease. Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on mortality (RR 3.5, 95% CI 1.1-6, p=0.03). Metabolic syndrome significantly increased the risk of mortality among nondiabetic patients with stable coronary artery disease (RR 3.5; 95% CI 1.1-6; P=0.03).