Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression

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This work aims to investigate how interferon-gamma and tumor necrosis factor-alpha influence the immunosuppressive functions of human umbilical-cord-derived mesenchymal stem cells through PD-L1 expression.
Evaluation of PD-L1 expression in human umbilical-cord-derived mesenchymal stem cells after exposure to interferon-gamma and tumor necrosis factor-alpha.
Retrospective analysis of literature and previous studies regarding mesenchymal stem cells and immunosuppression.
Interferon-gamma and tumor necrosis factor-alpha significantly increased PD-L1 expression in mesenchymal stem cells.
Enhanced immunosuppressive capacity was observed, leading to potential applications in immunotherapy strategies.

Highlights the role of interferon-gamma and TNF-alpha in enhancing PD-L1 in mesenchymal stem cells, suggesting new immunotherapy approaches.

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Chen et al. (2023) studied this question.

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