What question did this study set out to answer?

The aim is to identify and characterize the peptide targeting signals required for the transport of firefly luciferase into peroxisomes.

Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase.

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Experimental study identifies a crucial signal for protein transport to peroxisomes, suggesting unique mechanisms.

The aim is to identify and characterize the peptide targeting signals required for the transport of firefly luciferase into peroxisomes.
Examined the firefly luciferase gene in insect and mammalian cells for transport signals.
Identified necessary regions of luciferase for peroxisomal transport.
Demonstrated the sufficiency of region II as a peroxisomal targeting signal.
One identified targeting signal, located at the carboxy-terminus, is essential for luciferase transport to peroxisomes.
The peroxisomal targeting signal is a peptide of no more than twelve amino acids.
The targeting mechanism differs from that of other organelles like the endoplasmic reticulum and mitochondrion.

Gould et al. (1987) studied this question.

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