Key result
LVNC presents as a highly variable morphological trait rather than an inherent cardiomyopathy.
The term 'LVNC cardiomyopathy' should be used cautiously, as left ventricular noncompaction morphology can occur in healthy individuals and athletes without functional impairment.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“We envisage the scientific community will move away from the term 'LV non-compaction', which is misleading, to use 'excessive trabeculation' which can be observed across a wide spectrum of health and disease states.”
“Based on the available evidence, this expert consensus provides pragmatic recommendations on the clinical management of adults with incidental excessive trabeculation and those diagnosed with hypertrophic or dilated cardiomyopathy along with excessive trabeculation. Evidence is relatively sparse in children with excessive trabeculation, so this population may follow a different clinical trajectory – hence the need for further research.”
LVNC anatomy alone should not prompt cardiomyopathy diagnosis; leaves open need for functional and prognostic criteria in research.
Arbustini et al. (2016) conducted a review in Left ventricular noncompaction. Left ventricular noncompaction is a morphological trait with extreme individual variability that can occur in healthy subjects and does not inherently equate to a cardiomyopathy.
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