Paracoccus species occupy diverse habitats, yet their exopolysaccharide (EPS) biosynthetic capacity remains underexplored. We performed an in silico comparative analysis of four species: P.aerodenitrificans, P.saliphilus, P.sanguinis , and P.zhejiangensis , using annotated genomes. Genome-scale mining integrated orthologous clustering, functional profiling, transporter annotation, and antiSMASH-based detection of biosynthetic gene clusters. The four genomes showed comparable sizes and broadly conserved functional repertoires, with a substantial shared core and limited species-specific innovations. Saccharide-related clusters dominated the secondary-metabolite landscape. Candidate EPS loci and nucleotide-sugar pathways were conserved across species, with expansions in glycosyltransferases and transport systems consistent with EPS production. Together, these data reveal that the four analyzed Paracoccus genomes contain conserved glycan-related genes and candidate EPS-associated features, suggesting that EPS biosynthetic potential may be shared across these selected representatives while highlighting strain-level specializations.
Halimi et al. (Mon,) studied this question.
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