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June 19, 2026ACS Applied Bio Materials

Gelatin-Syringaldehyde-Zinc Hydrogel: A Triple-Action Bioactive Dressing for Infected Wound Regeneration

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Authors

LYLingxiu YangHunan UniversityZZZheng ZhouHebei University of EngineeringSZShuai ZhuHunan University

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Implication

Randomized trial demonstrates improved wound healing in infected models, suggesting innovative hydrogel use.

Key Points

  • This research aims to develop a multifunctional hydrogel that promotes wound healing while combating bacterial infections and oxidative stress.
  • Developed gelatin-syringaldehyde-zinc hydrogel via Michael addition and cross-linking.
  • Conducted in vitro assessments for biocompatibility and efficacy in promoting cell activities.
  • Tested the hydrogel in a mouse model with Staphylococcus aureus-induced wounds.
  • GSZ hydrogel significantly accelerated wound closure compared to controls (specific metrics not provided).
  • Enhanced epithelial regeneration and stimulated angiogenesis observed in treated wounds.
  • Remarkable collagen deposition noted, indicating improved tissue repair.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a34dbc465a5b0777af2c6a6https://doi.org/10.1021/acsabm.6c00546
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