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June 19, 2026Scientific ReportsOpen Access

The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial

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Randomized trial evaluates astaxanthin effects on inflammation and lipid levels in heart failure, suggesting potential benefits.

To evaluate the impact of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in heart failure patients.
Randomized controlled double-blind trial with 80 patients having stage C/D heart failure and LVEF < 50%
Participants received 20 mg/day of astaxanthin or placebo for 8 weeks
Assessment of inflammatory markers, lipid profile, and anthropometric indices pre- and post-intervention.
Astaxanthin significantly reduced TNF-α levels (-3.19 vs. -1.26 pg/mL; p = 0.013)
MCP-1 concentrations decreased significantly (-2.47 vs. 6.48 pg/mL; p = 0.004)
VLDL levels decreased significantly (p = 0.024), but total cholesterol showed a non-significant reduction (p = 0.061).

Mohammadi et al. (2026) studied this question.

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