Decoding a Case of Mpox Mimicry in a Patient With Fever and Bloody Diarrhea

Mpox, a zoonotic infection increasingly reported outside endemic regions, can mimic other sexually transmitted and enteric infections. We describe a 21-year-old HIV-negative man who presented with fever, bloody diarrhea, and a pustular rash. Work-up revealed co-infection with herpes simplex virus type 1 proctitis, Campylobacter jejuni colitis, and group A Streptococcus bacteremia. Despite antiviral therapy, persistent rash led to biopsy-confirmed Mpox. The patient recovered with supportive care alone. This case underscores the diagnostic challenges posed by overlapping infections and highlights the need to consider Mpox in atypical proctitis and rash presentations among at-risk populations.