Multisystem Neuroimmune, Autonomic, Thromboembolic, and Vestibular Dysfunction Following mRNA COVID-19 Vaccination: A Case Report

Multisystem neurologic, autonomic, immune, and vestibular complications following mRNA COVID-19 vaccination remain rare. We report a previously healthy woman who developed profound dysautonomia, constant neuropathic pain, persistent postural-perceptual dizziness, mast cell activation–like symptoms, acquired thrombophilia requiring anticoagulation, migraines, and new-onset generalized seizures shortly after vaccination. Symptoms persisted despite extensive evaluation and treatment. Although causality cannot be established from a single case, the temporal association, extensive diagnostic evaluation, and biological plausibility warrant clinical awareness and further study.