What question did this study set out to answer?

This study aims to understand the impact of melatonin and its receptors on retinal structure and function in mice.

June 19, 2026Sleep ScienceOpen Access

Melatonin Modulates Visual Function and Cells Viability in the Mouse Retina

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Randomized trial investigates the role of melatonin receptors on retinal function and morphology in mice, suggesting implications for retinal health.

This study aims to understand the impact of melatonin and its receptors on retinal structure and function in mice.
Crossed targeted MT1 receptor knockout mice (MT1-/-) with C3Hf+/+ background to study retinal effects.
Measured scotopic electroretinogram (ERG) responses and assessed retinal morphology at three different ages (3, 12, and 18 months).
Injected melatonin during the day to observe effects on ERG responses in wild type (WT) and MT1-/- mice.
MT1-/- mice showed significant reduction in photoreceptor nuclei at 12 and 18 months compared to C3Hf+/+.
Diurnal rhythm of ERG responses observed in WT mice was absent in MT1-/- mice.
Melatonin injection increased scotopic threshold and ERG amplitudes in WT but not in MT1-/- mice.

G Tosini (2009) studied this question.

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Randomized trial investigates the role of melatonin receptors on retinal function and morphology in mice, suggesting implications for retinal health.