Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 19, 2026European Journal of ImmunologyOpen Access

Methodological Insights Into T‐Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation

View Full Paper
Ask AI
Bookmark
Share

Authors

NANekruz AbdulhaqovTechnological University of TajikistanLMLady Tatiana Albarracin MeloOtto-von-Guericke University MagdeburgIMInes MeinertOtto-von-Guericke University Magdeburg

Discussion

Loading...

Member takes

Implication

Compares T-cell activation through CD3/CD28 and PMA/Ionomycin, highlighting key differences in signaling pathways.

Key Points

  • This research investigates the distinct signaling pathways activated by CD3/CD28 and PMA/ionomycin stimulation in human T cells.
  • Examined primary human T cells stimulated with CD3/CD28 and PMA/ionomycin.
  • Analyzed the activation of ERK and IL-2/STAT5 signaling pathways.
  • CD3/CD28 stimulation activates both ERK and IL-2/STAT5 pathways.
  • PMA/ionomycin primarily induces ERK-dependent proliferation with significant IL-2 production.
  • Different activation methods yield fundamentally distinct signaling outcomes.

Cite This Study

Abdulhaqov et al. (2026) studied this question.

synapsesocial.com/papers/6a34dcea65a5b0777af2cdffhttps://doi.org/10.1002/eji.70227
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors2013 · 59 citations
  2. 2T Cell Activation2009 · 2,162 citations
  3. 3Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells2023 · 23 citations
  4. 4Mechanisms of T cell activation by the calcium ionophore ionomycin.1989 · 224 citations
  5. 5Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids2000 · 172 citations