What question did this study set out to answer?

This study investigates the role of CCR6-CCL20 signaling in Ig isotype switching during gut inflammation.

June 19, 2026The Journal of Immunology

CCR6-CCL20 signaling modulates immunoglobulin isotype switching at the mucosal barrier during gut inflammation

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This study investigates the role of CCR6-CCL20 signaling in Ig isotype switching during gut inflammation.
Used dextran sodium sulfate (DSS)–induced gut inflammation model in C57BL/6 mice.
Measured IgA+ and IgG1+ B cell populations and serum levels during inflammation.
Examined phosphorylation of AKT/mTOR/STAT3 pathways in B cells upon CCL20 stimulation.
DSS elevated CCL20 production and enhanced differentiation of IgA+ B cells in gut-associated lymphoid tissues.
Reduction in IgG1+ B-cell populations and serum IgG1 levels observed in a CCR6-dependent manner.
Rapamycin treatment inhibited CCL20-driven IgA+ B cell differentiation, indicating mTOR's role.

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Implication

Randomized trial reveals CCR6-CCL20 signaling regulates Ig isotype switching in gut inflammation, suggesting therapeutic targets for inflammatory diseases.

Cite This Study

Padghan et al. (2026) studied this question.

synapsesocial.com/papers/6a34dd1d65a5b0777af2ce9c https://doi.org/10.1093/jimmun/vkag150

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Implication

Randomized trial reveals CCR6-CCL20 signaling regulates Ig isotype switching in gut inflammation, suggesting therapeutic targets for inflammatory diseases.

CCR6-CCL20 signaling modulates immunoglobulin isotype switching at the mucosal barrier during gut inflammation

Key Points

Discussion

Implication

Cite This Study

CCR6-CCL20 signaling modulates immunoglobulin isotype switching at the mucosal barrier during gut inflammation

Key Points

Discussion

Implication

Cite This Study

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