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June 19, 2026The Journal of Clinical Endocrinology & Metabolism

Serum free triiodothyronine as an adjunctive marker for thyroid hormone status in athyreotic patients on levothyroxine

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Authors

YNYuji NagayamaSTSeigo TachibanaTFTakashi Fukuda

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Overview

Retrospective study identifies serum free triiodothyronine as a marker for thyroid hormone status in athyreotic patients on levothyroxine, suggesting its clinical relevance.

Key Points

  • This study aims to identify reliable biochemical markers for assessing thyroid hormone status in athyreotic patients on levothyroxine.
  • Single-center retrospective, cross-sectional study of athyreotic patients on levothyroxine.
  • Classification based on TSH, FT3, and FT4 levels and comparison of metabolic markers across groups.
  • 426 patients evaluated for serum FT3 and FT4 levels with propensity score matching applied.
  • 58% of patients exhibited normal serum FT3 and FT4 levels, while 21% had normal FT3 and elevated FT4.
  • Patients with low FT3 showed significantly elevated alanine transaminase and body mass index compared to those with normal FT3.
  • Lower FT3 was associated with altered metabolic markers, suggesting FT3 could indicate peripheral thyroid hormone action.

Cite This Study

Nagayama et al. (2026) studied this question.

synapsesocial.com/papers/6a34dd1d65a5b0777af2cec8https://doi.org/10.1210/clinem/dgag220
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Also Consider

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  1. 1Risk of death and adverse effects in patients on Liothyronine: a multi-source systematic review and meta-analysis2025
  2. 2Canadian Endocrinologists' Perspectives on Treatment With Thyroid Hormone Substitutions in Euthyroid and Hypothyroid Patients: A 2023 THESIS Questionnaire Survey.2025
  3. 3Thyroid function related symptoms during levothyroxine monotherapy in athyreotic patients2019 · 16 citations
  4. 4Use of liothyronine (T3) in hypothyroidism: Joint British Thyroid Association/Society for endocrinology consensus statement2023 · 31 citations
  5. 5Thyroid hormone use in clinical practice by Israeli endocrinologists: a THESIS* questionnaire survey2025 · 2 citations