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This study aims to optimize an electrochemical aptasensor for the detection of glycated hemoglobin (HbA1c) as a diabetes biomarker.

June 19, 2026Journal of SensorsOpen Access

Optimization of Electrochemical Aptasensor to Detect Glycated Hemoglobin (HbA1c) as a Diabetes Mellitus Biomarker

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This study aims to optimize an electrochemical aptasensor for the detection of glycated hemoglobin (HbA1c) as a diabetes biomarker.
Developed an electrochemical aptasensor using screen-printed carbon electrode modified with gold nanoparticles.
Immobilized a biotinylated aptamer onto the electrode surface for detection.
Evaluated signal response using differential pulse voltammetry and electrochemical impedance spectroscopy.
The optimal aptamer concentration was 1.5 µg/mL with a 60 min incubation time for the aptamer and 4 min for HbA1c.
Detection limit was 1.17% and quantification limit was 3.5%, within a dynamic range of 2%–15%.
The aptasensor showed a significant decrease in current upon HbA1c binding, indicating sensitive and selective detection.

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Randomized trial demonstrates sensitive detection of HbA1c in diabetes, highlighting potential for point-of-care testing.

Mulyani et al. (2026) studied this question.

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