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June 19, 2026Open Access

Formulation and Evaluation of Azithromycin and Paracetamol a Combination Therapy as Suppositories Novel Drug Delivery Systems

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Authors

MSMahmoud Mahyoob Alburyhi1*, Tawfeek A. A. Yahya2, Maged Alwan Noman1, Abdalwali Ahmed Saif1

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Overview

Randomized trial develops and evaluates a novel rectal suppository to enhance adherence in children, suggesting effective treatment for infections.

Key Points

  • The study aimed to create and assess a stable rectal formulation combining Azithromycin and Paracetamol for pediatric patients.
  • Developed 11 rectal suppository formulations using fusion methods with PEG and Witepsol bases.
  • Optimized formulation F11 was evaluated for disintegration time, pH, drug content, and physical properties using HPLC.
  • Conducted assessments on physical characteristics like appearance, weight variation, and disintegration time.
  • The optimized formulation F11 showed a rapid mean disintegration time of 4 minutes and 5 seconds at 37°C.
  • HPLC analysis confirmed Azithromycin and Paracetamol contents were 104.87% and 108.76% of the label claim, respectively.
  • Lipophilic Witepsol® formulation met standard requirements, while PEG-based formulations did not.

Cite This Study

Mahmoud Mahyoob Alburyhi1*, Tawfeek A. A. Yahya2, Maged Alwan Noman1, Abdalwali Ahmed Saif1 (2026) studied this question.

synapsesocial.com/papers/6a34dd8765a5b0777af2d359https://doi.org/10.5281/zenodo.20729229
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