Reveals aging disrupts coordination in ovarian cycles, linking cellular dynamics and tissue changes in mice, suggesting implications for reproduction.
Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, revealing that reproductive decline reflects progressive loss of spatiotemporal coordination, linking altered cellular dynamics, tissue remodeling and inflammation across the ovary.
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Lan et al. (2026) studied this question.
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