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July 23, 2026Proceedings of the National Academy of SciencesOpen Access

Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition

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Authors

XWXifan WangJYJiping YangCJChen Jin

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Overview

Randomized trial reveals molecular mechanisms of aging in mouse ovaries, highlighting cellular senescence.

Key Points

  • This research aims to elucidate the molecular mechanisms driving reproductive aging and senescence during the estropausal transition in mice.
  • Developed a single-cell atlas of mouse ovaries across various reproductive stages.
  • Characterized ovary-specific senescent cells using senescence-associated β-galactosidase activity.
  • Analyzed transcriptomic changes and aging pathways during the estropausal transition.
  • Irregularly cycling ovaries showed accelerated aging features, including altered oxidative phosphorylation (P<0.01).
  • Increased expression of the senescence marker Cdkn1a observed in irregularly cycling ovaries compared to regularly cycling ones.
  • Dysregulation of hormone-related pathways was noted in granulosa cells during the estropausal transition.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a61af56faa9903c5116a398https://doi.org/10.1073/pnas.2600323123
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