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The aim is to evaluate cognitive impairment risk factors in COPD patients living at high altitude.

Exposure to indoor wood smoke, rather than hypoxemia, is a risk factor for cognitive impairment in COPD patients living at high altitude

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The aim is to evaluate cognitive impairment risk factors in COPD patients living at high altitude.
199 COPD patients with FEV1/FVC < 0.70 at high altitude were assessed for cognitive impairment using the Mini-Mental State Examination.
Evaluated variables included wood smoke exposure, age, educational level, arterial blood gases, diffusion capacity, and exercise performance.
Statistical analyses included chi-square test, unpaired t-test, and logistic regression for odds ratio calculations.
16.1% of patients exhibited cognitive impairment, predominantly mild (68.8%).
Cognitive impairment was significantly associated with more frequent wood smoke exposure (p<0.001) and lower arterial oxygen levels (p=0.032).
Exposure to wood smoke was linked to cognitive impairment with an odds ratio of 4.82 (95% CI: 1.62-14.33).

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Randomized trial identifies wood smoke as a risk factor for cognitive impairment in COPD patients, suggesting the need for targeted interventions.

González-García et al. (2026) studied this question.

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Randomized trial identifies wood smoke as a risk factor for cognitive impairment in COPD patients, suggesting the need for targeted interventions.