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June 19, 2026Journal of Inflammation ResearchOpen Access

Mucosal Involvement in Bullous Pemphigoid: Severity Indicator and Associated Clinical Features from a Retrospective Cohort Study

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Authors

SCShengnan CuiChinese Academy of Medical Sciences & Peking Union Medical CollegeBZBingjie ZhangChinese Academy of Medical Sciences & Peking Union Medical CollegeFCFangyuan ChenChinese Academy of Medical Sciences & Peking Union Medical College

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Overview

Retrospective cohort study evaluates mucosal involvement in bullous pemphigoid, suggesting severe clinical features in affected individuals.

Key Points

  • This study aims to evaluate the prevalence of mucosal involvement in bullous pemphigoid and its associated clinical features.
  • Retrospective cohort study involving 265 patients with bullous pemphigoid.
  • Comparison of clinical, laboratory, and treatment characteristics between patients with and without mucosal involvement.
  • Logistic regression analyses to identify factors associated with mucosal involvement.
  • 26.8% of patients had mucosal involvement, most commonly affecting the oral mucosa.
  • Patients with mucosal involvement had younger disease onset, higher hospitalization rates, and more infections.
  • Head/neck involvement (adjusted OR 8.276), hands/feet involvement (adjusted OR 34.559), and higher BPDAI scores were associated with mucosal involvement; peripheral eosinophilia was inversely associated (adjusted OR 0.027).

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a34ddaf65a5b0777af2d4e4https://doi.org/10.2147/jir.s608150
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Also Consider

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  1. 1Mucosal Involvement in Bullous Pemphigoid Is Mostly Associated with Disease Severity and to Absence of Anti-BP230 Autoantibody2018 · 44 citations
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  3. 3The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease2018 · 135 citations
  4. 4Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology ( EADV )2022 · 276 citations