Prospective cohort study investigates risk factors and mechanisms of posttransplant diabetes in kidney transplant recipients, indicating potential preventive strategies.
Key Points
The study aims to identify the incidence, risk factors, and underlying mechanisms of posttransplant diabetes mellitus (PTDM) in kidney transplant recipients.
Prospective observational study of 80 nondiabetic kidney transplant recipients (2023–2024).
Analyzed pretransplant and posttransplant clinical and metabolic parameters, including HOMA-IR and HOMA-β.
Used logistic regression and ROC curves to determine predictors of PTDM.
PTDM developed in 23.8% of recipients (n=19).
Pretransplant triglycerides >134.5 mg/dL (OR 1.05) and tacrolimus levels ≥7.5 ng/mL (OR 2.1) were independent risk factors.
Beta-cell dysfunction was indicated as the predominant mechanism, with significantly lower HOMA-β compared to HOMA-IR (P < 0.001).