Sociodemographic and Clinical Characteristics of Individuals Receiving Post-Exposure Prophylaxis (PEP) for HIV in the Republic of Cyprus: A Cross-sectional Study

Objective: This study aimed to describe the sociodemographic and clinical characteristics of individuals seeking PEP in the Republic of Cyprus and identify characteristics associated with PEP administration, willingness to use PrEP, and engagement with sexual health services. materials and methods: A retrospective cross-sectional study was conducted at the Grigorios HIV Reference Clinic, Larnaca General Hospital, from September 2022 to December 2024. Data from 214 individuals presenting after potential high-risk HIV exposure were collected using structured questionnaires. Descriptive statistics and bivariate analyses (t-tests and chi-square tests) were performed to explore possibleassociations (p<0.05). Methods: A cross-sectional study was conducted at the Grigorios HIV Reference Clinic, Larnaca General Hospital, from September 2022 to December 2024. Data from 214 individuals presenting with potential high-risk HIV exposure were collected using structured questionnaires, administered at presentation. Descriptive statistics and bivariate analyses (t-tests and chi-square tests) were performed to explore possible associations (p<0.05). Results: Of the 214 participants, 209 (97.7%) received PEP, with 48.1% presenting within 24 hours. The majority were male (85.5%), aged 25-34 (43.9%), and identified as men who have sex with men (MSM). Unprotected anal intercourse (44.9%) was the most common exposure type. Sexual orientation was linked to the type of exposure (p<0.001). Willingness to use PrEP was associated with prior PEP/PrEP use (p<0.001), and willingness to attend sexual health clinics was correlated with recent HIV testing (p=0.030). Discussion: PEP services in Cyprus appear to reach key high-risk groups, specifically MSM, with generally timely access. However, late presentations, reported access and awareness barriers regardless of fully reimbursed PEP, and infrequent HIV testing suggest persistent gaps in equitable prevention coverage. Decentralising services and strengthening testing and education are required alongside PrEP application. Conclusion: High PEP uptake and timely access were observed among MSM in Cyprus, though gaps in PrEP awareness and engagement with preventive services remain.