What question did this study set out to answer?

This research examines how social disadvantages impact neurobiological changes in individuals with schizophrenia-spectrum psychotic conditions (SSPCs).

June 19, 2026JAMA Psychiatry

Social Determinants of Health and Neurobiology Across the Schizophrenia Course

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Authors

JHJessica P.Y. HuaUniversity of California, San Francisco KBKaitlyn Dal BonUniversity of California, San Francisco

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Implication

Systematic review examines the link between social determinants and neurobiological changes in individuals with schizophrenia spectrum conditions, suggesting important implications for treatment.

Key Points

This research examines how social disadvantages impact neurobiological changes in individuals with schizophrenia-spectrum psychotic conditions (SSPCs).
Systematic literature search in PsycInfo, PubMed, and Web of Science until January 2026.
114 articles included, focusing on associations between social determinants of health (SDOH) and neurobiological measures.
Quality assessment using the Joanna Briggs Institute Checklist to evaluate study impacts.
Exposure to adverse SDOHs correlated with neurobiological abnormalities like cortical thinning and brain volume reduction.
Out of 114 articles, 83 discussed structural brain measures, indicating significant findings in this area.
Evidence suggests a strong intermediary link between SDOHs and clinical outcomes in SSPC.

Cite This Study

Hua et al. (2026) studied this question.

synapsesocial.com/papers/6a34de7065a5b0777af2dd65 https://doi.org/10.1001/jamapsychiatry.2026.1312

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Implication

Systematic review examines the link between social determinants and neurobiological changes in individuals with schizophrenia spectrum conditions, suggesting important implications for treatment.

Social Determinants of Health and Neurobiology Across the Schizophrenia Course

Discussion

Member takes

Implication

Key Points

Cite This Study

Social Determinants of Health and Neurobiology Across the Schizophrenia Course

Discussion

Member takes

Implication

Key Points

Cite This Study

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